Digital Microfluidic Droplet Adapter for Interconnection of Biochips
نویسندگان
چکیده
As Digital Microfluidic Biochips (DMFBs) become more and more popular, largescale integration of DMFB microarrays is desirable. Multiple DMFBs with different electrode size from various manufacturers may need to be integrated into a single chip. However, the incompatibility of electrode size poses a problem for the integration of multiple DMFBs. In this paper, a droplet size adapter to convert microfluidic droplets into different sizes is reported. In this way, the droplets coming out from one DMFB can be input to another DMFB to continue the processing. The function of the proposed adapter is verified with COMSOL simulation. COMSOL Multiphase Flow Model, Laminar TwoPhase Flow (tpf) and Level Set method are used in the simulation. The adapter allows bi-directional size conversion of microfluidic droplets. Reverse conversion can be achieved by simply reversing the voltage sequence. The proposed adapter can be used for the integration of multiple DMFBs with different electrode sizes.
منابع مشابه
Fault Tolerant DNA Computing Based on Digital Microfluidic Biochips
Historically, DNA molecules have been known as the building blocks of life, later on in 1994, Leonard Adelman introduced a technique to utilize DNA molecules for a new kind of computation. According to the massive parallelism, huge storage capacity and the ability of using the DNA molecules inside the living tissue, this type of computation is applied in many application areas such as me...
متن کاملReconfiguration Techniques for Digital Microfluidic Biochips
As digital microfluidic biochips become widespread in safety-critical biochemical applications, system dependability emerges as a critical performance parameter. The dynamic reconfigurability inherent in digital microfluidic biochips can be utilized to bypass faulty cells, thereby supporting defect/fault tolerance. In this paper, we propose three different reconfiguration techniques and the cor...
متن کاملDesign and Simulation of High-throughput Microfluidic Droplet Dispenser for Lab-on-a-Chip Applications
Digital Microfluidic Biochips (DMFBs) have been widely used in Lab-on-a-Chip (LoC) for disease diagnosis and treatment applications. Biological sample to be processed are originally analog continuous flow. To convert it into digital droplets for DMFB processing, a microfluidic droplet dispenser acting as an analog-to-digital converter (ADC) is needed. In this paper, a highthroughput analog-to-d...
متن کاملDesign, Optimization, and Test Methods for Micro-Electrode-Dot-Array Digital Microfluidic Biochips
Digital microfluidic biochips (DMFBs) are revolutionizing many biochemical analysis procedures, e.g., high-throughput DNA sequencing and point-of-care clinical diagnosis. However, today’s DMFBs suffer from several limitations: (1) constraints on droplet size and the inability to vary droplet volume in a fine-grained manner; (2) the lack of integrated sensors for real-time detection; (3) the nee...
متن کاملDesign Automation and Test Techniques for Microfluidic Biochips
Microfluidics-based biochips, also referred to as lab-on-a-chip (LoC), are devices that integrate fluid-handling functions such as sample preparation, analysis, separation, and detection. This emerging technology combines electronics with biology to open new application areas including point-of-care diagnosis, on-chip DNA analysis, and automated drug discovery. As digital microfluidic biochips ...
متن کامل